In vivo > 항암유효성평가지원센터

유효성평가와 기전 규명을 위한 다양한 동물모델을 보유하고 있으며, 이들을 활용하여 임상시험 연계성이 높은 최적의 in vivo 효능 평가 서비스 제공

보유모델

모델

암종

Xenograft

Syngeneic

Subcutaneous 

Bladder

UMUC3

Breast

MCF7, MDA-MB231

4T1, 4T1-Luc-TdTomato

Burkitt’s lymphoma

Raji

Cervix

A431

Colon

DLD1, HCT8, HCT15, HCT116, HT29, LoVo, RKO, SW620

CT26, MC38

Kidney

SN12C

Leukemia

K562, MV4-11

Liver

Hep3B, HepG2, Huh7, SK-Hep1

Lung

A549, HCC78, HCC827, H1299, PC9

LLC1

Melanoma

UACC-62

B16/F10

Ovary

OVCAR-3-Luc

Pancreas

AsPC-1, BxPC-3, MiaPaCa2

Prostate

DU-145 , PC3

TRAMP-C1

Stomach

NCI-N87

Orthotopic

Breast

4T1-Luc-TdTomato

Colon

HCT116-Luc, HT29-Luc

 

Leukemia

MOLM-13

Liver

HepG2-Luc-Fluc

Lung

A549-Luc

Ovary

ES-2-Luc

ID8

Pancreas

AsPC-1-Luc, BxPC-3-Luc

PAN02

Prostate

TRAMP-C1

Metastasis

Breast

4T1-Luc-TdTomato(Intracardiac Injection),

4T1-Luc-TdTomato(Intravenous Injection)

Leukemia

WEHI-3

Ovary

ES-2-Luc (Orthotopic Injection), OVCAR3-Luc (Intraperitoneal Injection), SK-OV-3-Luc (Intraperitoneal Injection)

Spontaneous Model

Lung

Lung (Mutation: p53/ras)

Genetically Engineered Mouse

Immuno Oncology

CTLA-4 Knock-out Mouse, PD-1 Knock-out Mouse

Lung

Ba/F3/Her2 insertion cell line,
EGFR mutant(L858R+T790M+C797S)-induced lung cancer in mouse

서비스 내용

  • 수요자 맞춤형 시험 디자인
  • Tumor growth inhibition/delay 시험
    • 단독 처리 (single treatment)
    • 병용 처리 (combination treatment)
  • Kaplan-Meier survival 시험
  • Metastasis inhibition 시험
  • Radiotherapy response 시험
  • Histological analysis
    • Tissue preparation, IHC, TUNEL, DNA/RNA/protein extraction 등
    • Histopathology
  • MOA & POC 검증
  • In vivo imaging
    • MRI, PET, PET-MR, CT, Optical imaging 활용 시험
    • PD, tissue distribution

서비스 예시

대장암 subcutaneous xenograft model에서 in vivo 항암 효능 평가