Immuno-Oncology > 항암유효성평가지원센터

Immune-competent animal model을 이용한 immuno-modulatory agents의 임상적 유용성 검증 서비스를 제공하며, 의뢰자의 요구에 맞는 모델 제조 및 이를 활용한 전방위적 평가 서비스 제공

보유모델

모델

암종

세포주명

Subcutaneous Syngeneic Model

Breast

4T1 (Balb/c), 4T1-Luc-TdTomato (Balb/c)

Colon

CT26.WT (C57BL/6), MC-38 (C57BL/6)

Fibrosarcoma

FSa-II (Balb/c)

Lung

LLC1 (C57BL/6)

Melanoma

B16/F10 (C57BL/6)

Ovary

ID8 (Balb/c)

Prostate

TRAMP-C1 (C57BL/6)

Orthotopic Syngeneic Model

Breast

4T1 (Balb/c), 4T1-Luc-TdTomato (Balb/c)

Lung

LLC1-Luc (C57BL/6)

Pancreas

PAN02

Prostate

TRAMP-C1 (C57BL/6)

Metastasis Syngeneic Model

Breast

4T1-Luc-TdTomato (Mammary Fat Pad Injection)

4T1-Luc-TdTomato (Intracardiac Injection)

4T1-Luc-TdTomato (Intravenous Injection)

Leukemia

WEHI-3 (Mouse Leukemia)

Spontaneous Model (GEM)

Lung

Induced by p53/ras mutation

Genetically Engineered Mouse (GEM)

Immuno-Oncology

CTLA-4 knock-out mouse, PD-1 knock-out mouse

Others

Asan NSG mouse

서비스 내용

  • 수요자 맞춤형 시험 디자인 (in vitro, in vivo, ex vivo)
  • 마우스 모델을 이용한 Tumor growth inhibition/delay 시험
  • 개발 약물의 단독 투여 및 기존 면역항암제 (ex. anti-PD-(L)1, anti-CTLA4 등)와의 병용 투여 효능 평가
  • FACS를 이용한 tumor microenvironment 내의 면역세포 immunophenotyping Histological analysis (Tissue preparation, IHC, TUNEL)
  • In vivo imaging
  • Live animal IVIS imaging, MRI, PET, PET-MR, CT
  • ADCC (Antibody-dependent cell mediated cytotoxicity), CDC (Complement dependent cytotoxicity) assay
  • Treg (Regulatory T cell) suppression assay
  • Metastasis inhibition assay
  • Immuno-radiotherapy response assay
  • Mouse tumor-infiltrated lymphocyte (TIL) analysis
  • 사람 T세포 분석: MLR assay / CEFT assay /CMV Antigen Recall Assay
  • PD-1:PD-L1 Inhibitor Screening Assay

서비스 예시

MC38 tumor 내의 tumor infiltrating lymphocytes 분석